Diego's Downtown is located at 224 E 3rd St. Santa Ana, CA 92701. Call Us 714-558-8257. Bar, Mexican Restaurant, Bars, Restaurants, Restaurant. Located in the heart of Santa Ana, Diego's is the next level in the downtown dining experience.  Diego's provides tasty food, and a standout selection of wine and signature cocktails.  The perfect place for a delicious meal or drinks with friends. Business Hours: Sun and Mon Closed, Tue and Wed 03:00 PM-10:00 PM, Thu 03:00 PM-12:00 AM, Fri 03:00 PM-01:00 AM, Sat 05:00 PM-01:00 AM.