The Hotel Roanoke & Conference Center is located in the Gainsboro neighborhood in downtown Roanoke, Virginia. From meetings, bridge parties, dances, teas and luncheons from the old days to the present, they turned the Hotel into Roanoke's social and cultural center. The Hotel Roanoke & Conference Center has 330 luxuriously appointed guestrooms and a 63,000- square-foot, high-tech conference center.